Three US service members were killed Tuesday by an improvised explosive device near the city of Ghazni, Afghanistan, the US military announced.
The Taliban, which control large parts of Ghazni province, claimed responsibility for the attack, which also wounded an American civilian contractor.
Lt. Ubon Mendie, a military spokesman, said the wounded were evacuated and are receiving medical care.
No other details about the deadly incident were available.
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The deaths are the latest in a growing toll on USA forces in Afghanistan following the death of an army Ranger following an operation against al Qaeda militants in Nimruz province on Saturday.
On Saturday, Sgt. Leandro A.S. Jasso, a 25-year-old Army Ranger, was killed during an operation against al-Qaeda in southwestern Nimroz province, which borders Iran and Pakistan.
Taliban militants said they carried out the attack, their latest near the strategic city south of the capital.
Resolute Support said that "an initial review indicates Sgt. Jasso was likely accidentally shot by our Afghan partner force" and "there are no indications he was shot intentionally".
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In the past several weeks, the insurgents also have launched assaults on villages in rural districts of the province that are populated by minority ethnic Hazara Shiites.
With Afghan security forces struggling to hold back increasingly confident Taliban fighters and Western appetite for further commitments uncertain, the conference comes at a sensitive moment. "All of us, and throughout our coalition of 41 nations, recognize the threats posed by groups such as al Qaeda and ISIS and are determined to fight them here".
During that same period, 58 US troops were killed, he said.
The soldier's death follows a spate of so-called "insider attacks" that have rattled foreign troops tasked with training and assisting Afghan security forces. The great majority of USA forces withdrew by the end of 2014, but those still in the country often are involved in supporting combat situations on the ground as well as by air.
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