Both teams were already assured of spots in the knockout round, but Uruguay's victory put it at the top of Group A and looking toward a match in Sochi on Saturday against Portugal.
The host nation put five goals past Saudi Arabia in the opening match of the tournament before beating Mohamed Salah and co 3-1 to put themselves top of Group A. "Those who know what physiology is, we went through the Confederations Cup, we did our preparations for that and the condition of the national team then was very good, " he said.
Possible opponents either for Russian Federation or Uruguay in the Last 16 round will be decided after their duel in Samara later on Monday and they are now Portugal, Spain and Iran.
"Today we see the team with enormous potential and outstanding stamina", the 71-year-old Uruguayan head coach stated.
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Substitute Felipe Baloy rewarded them with a consolation goal in the 78th minute, sliding home a free kick that was Panama's first goal in their debut World Cup .
With both teams already qualified for the last 16, Russian Federation coach Stanislav Cherchesov also chose to make three changes to the side that beat Egypt 3-1.
It was Suarez's seventh goal in three World Cups, while it was only a third for Cavani.
Edinson Cavani scored his first goal of this World Cup in the last minute of regular time.
Uruguay doubled their lead in the 23rd minute when Diego Laxalt's shot from the edge of the area deflected off Cheryshev, leaving Akinfeev wrong-footed.
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Oscar Tabarez made four personnel changes for this fixture with the idea, presumably, to both rest players for the second stage and - perhaps more critically - to happen upon a line-up that made the most of Uruguay's gifts.
Uruguay's Edinson Cavani celebrates scoring their third goal with Diego Godin.
The goal for Suarez is his second of the World Cup, which leads Uruguay. "We did not marshal thoughts at the beginning of the match, but players rode roughshod over", Cherchesov stresses.
In particular, he sounded optimistic that his players might learn valuable lessons from their mistakes against the South Americans: "From one side, it's bad that we lost, from another, that kind of slap is useful sometimes", he said. Although the match was not crucial, we wanted to take the first place [in the group].
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