Here, we tackle the tricky proposition that is picking the strongest XI from the players now in line to feature.
While this combined XI will serve up some contentious decisions, there will be little argument over Hugo Lloris' position between the sticks.
It is seven years since Tottenham last won away at Liverpool, who have emerged victorious from five of the last seven meetings on their home turf. Serge Aurier will return to the side in defense, while only Toby Alderweireld and Danny Rose are doubts for Pochettino.
Victory for third-place Liverpool at Anfield would open up a five-point gap to Tottenham, a healthy buffer for Jurgen Klopp's team who have lost only once in 16 league games.
Virgil van Dijk will most likely be name in the starting lineup after being rested against Huddersfield during the midweek.
So, how will Spurs line-up this weekend?
Klopp: Jamie Carragher needs to lose weight, not Virgil van Dijk
The Reds have conceded 29 times in 25 games in the Premier League this season to raise concerns about Jurgen Klopp's defence. Philippe Coutinho is not worth that [£146m], he's not that good.
"To us, this game is a classic". Tottenham pride themselves on keeping it watertight at the back, particularly on the road against top opponents.
The similarities do not stop there as both sides have played some outstanding football, but been plagued by inconsistency.
Tricky choices must therefore be made in attack, but first comes the equally-difficult decision of selecting two holding midfielders.
Pochettino also took time to cite the examples of Erik Lamela, Moussa Sissoko and Heung-Min Son, who have all needed time to adapt after arriving in England, and says the fact that Lucas is no Neymar, Lionel Messi or Cristiano Ronaldo makes it even clearer that there will be no added pressure on him.
Liverpool went 18 games unbeaten off the back of that and despite back-to-back defeats at the end of January, they will hope to prove those losses were only minor setbacks with a statement triumph over their rivals. However, it is not just his final actions that pose a threat. "The Brazilian is very quick and gives them something they have not otherwise got down the right".
In addition to Christian Eriksen scoring the opener against United after only 11 seconds, Tottenham's relentless energy and pressure throughout was an outstanding feature. You don't often keep United as far away from your goal as Spurs did in that game.
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Given the time of year, it would be surprising if there weren't at least a few Patriots players under the weather. Gronkowski was flattened by Jaguars safety Barry Church just before the end of the first half and didn't return.
Where do you begin with Salah? The Englishman leads the Premier League goalscoring charts with 21 goals this season.
Liverpool, and Mane, will be looking to capitalise.
They then enjoyed three consecutive wins over Manchester City between September 2015 and October 2016, including a 4-1 win at White Hart Lane.
Tottenham will look to pile on the pressure from the get-go, with Pochettino directing his players to press high up the field in order to force Liverpool's defenders into making mistakes.
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The documents were in two locked filing cabinets sold at an ex-government sale in Canberra . They were sold off cheaply because they were heavy and no one could find the keys.
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